GTP Binding Protein 3, Mitochondrial (GTPBP3)

Mss1 is a yeast mitochondrial GTP-binding protein that functionally interacts with 15S rRNA. The variants are generated by alternative splicing and through the use of alternate polyadenylation signals. Two variants differ only in their 3-prime UTRs and encode an identical 492-amino acid protein with a calculated molecular mass of 52.0 kD. Two other variants encode an identical 471-amino acid protein, and another variant encodes a 524-amino acid protein. GTPBP3 contains a typical mitochondria targeting presequence, 2 GTP-binding domains, a p21 RAS-like domain, and an SRC homology-3 (SH3) domain. GTPBP3 shows extensive conservation of amino acid sequences with Mss1 homologs from several diverse species, including bacteria, yeast, and nematode. Mouse and human GTPBP3 share 81% amino acid identity.