GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)

KIR; Kinase-Inducible Ras-Like Protein; GTP-binding mitogen-induced T-cell protein; GTP-binding protein GEM
GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)
GEM and RAD, the product of a gene overexpressed in skeletal muscle and in individuals with type II diabetes mellitus, constitute a new family of RAS-related GTP-binding proteins. The distinct structural features of this family include the GTP-binding motif, extensive amino- and carboxyl-terminal extensions beyond the RAS-related domain, and a motif that determines membrane association. GEM was transiently expressed in human peripheral blood T cells in response to mitogen stimulation; the protein was phosphorylated on tyrosine residues and localized to the cytosolic face of the plasma membrane. Deregulated GEM expression prevented proliferation of normal and transformed NIH 3T3 cells. These results suggested that GEM is a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane.
Organism species: Homo sapiens (Human)
  • Protein RPJ042Hu01Recombinant GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • AntibodyPAJ042Hu01Polyclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • AntibodyMAJ042Hu21Monoclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • Assay KitSEJ042HuELISA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • Assay KitSCJ042HuCLIA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPJ042Mu01Recombinant GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • AntibodyPAJ042Mu01Polyclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • AntibodyMAJ042Mu21Monoclonal Antibody to GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • Assay KitSEJ042MuELISA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
  • Assay KitSCJ042MuCLIA Kit for GTP Binding Protein Overexpressed In Skeletal Muscle (GEM)Customize
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