GTPase Activating Protein SH3 Domain Binding Protein 2 (G3BP2)

G3BP2, Contains 1 NTF2 domain.Contains 1 RRM (RNA recognition motif) domain. Binds to the N-terminal domain of I-kappa-B-alpha. Probable scaffold protein that may be involved in mRNA transport.

Human ras-GTPase-activating protein (GAP120) SH3-domain-binding protein (G3BP) has recently been identified on the basis of its specific binding to the GAP120 SH3 binding domain. Mouse G3BP also contains an RGG domain, an acid-rich amino acid domain, and several SH3 domain-binding consensus sequences, indicating that mammalian G3BPs represent a new family of signal transduction proteins which connect tyrosine kinase-linked receptors to cellular RNA metabolism.