GTPase, IMAP Family, Member 5 (GIMAP5)

GIMAP5 encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1.The deduced 307-amino acid protein contains 5 motifs conserved in GTP-binding proteins and a putative C-terminal transmembrane region. IAN4L1 shares 46% identity with IMAP1. Phylogenetic analysis showed that IAN4L1 is homologous to mouse Ian4.Northern blot analysis detected a 2.1-kb transcript in myeloid cells. Cell fractionation and immunocytochemical analysis revealed mitochondrial localization. A truncation mutant lacking the C-terminal 20 amino acids localized diffusely throughout the cytoplasm.IAN4L1 gene contains 3 exons.