Gametocyte Specific Factor Like Protein 1 (GTSF1L)

GTSF1L, Belongs to the UPF0224 (FAM112) family. Contains 1 CHHC-type zinc finger. GTSF1 is localized to the cytoplasm of these cells in the adult testis. The Gtsf1/Cue110-null mice grew normally and appeared healthy; however, the males were sterile due to massive apoptotic death of their germ cells after postnatal day 14.Gtsf1/Cue110-null male meiocytes ceased meiotic progression before the zygotene stage. Gtsf1/Cue110 gene is essential for spermatogenesis beyond the early meiotic phase. the loss of the Gtsf1/Cue110 gene caused increased transcription of the long interspersed nucleotide element (Line-1) and the intracisternal A-particle (IAP) retrotransposons, accompanied by demethylation of their promoter regions.Gtsf1/Cue110 is required for spermatogenesis and involved in retrotransposon suppression in male germ cells.