Gamma-Glutamyl Carboxylase (gGCX)

Gamma-glutamyl carboxylase is an enzyme catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis.Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational modification. In humans, the gamma-glutamyl carboxylase enzyme is most highly expressed in the liver.

Gamma-glutamyl carboxylase is an enzyme which oxidizes Vitamin K hydroquinone to Vitamin K 2,3 epoxide, while simultaneously adding CO₂ to protein-bound glutamic acid (abbreviation = Glu) to form gamma-carboxyglutamic acid (also called gamma-carboxyglutamate, abbreviation = Gla).