Gamma-Glutamylcyclotransferase (gGCT)

GCTG; CRF21; Ggc; C7orf24; Cytochrome c-releasing factor 21

Gamma-Glutamylcyclotransferase (gGCT)
GGCT (EC 2.3.2.4) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis.
The deduced 188-amino acid protein has a calculated molecular mass of 21 kD. EST database analysis revealed moderate GGCT expression in a wide range of human tissues, with highest levels in bladder and salivary gland. Database analysis identified GGCT orthologs in a range of species from C. elegans to mammals, but not in plants.GGO-induced apoptosis was inhibited by a dominant-negative mutation of JNK (MAPK8) that impeded JNK signaling, suggesting involvement of JNK and CRF21 in GGO-induced apoptosis.The enzymatic kinetics were similar to those of GGCT purified from human erythrocytes.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)