Gamma-Glutamylcyclotransferase (gGCT)
GCTG; CRF21; Ggc; C7orf24; Cytochrome c-releasing factor 21
GGCT (EC 2.3.2.4) catalyzes the formation of 5-oxoproline (pyroglutamic acid) from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis.
The deduced 188-amino acid protein has a calculated molecular mass of 21 kD. EST database analysis revealed moderate GGCT expression in a wide range of human tissues, with highest levels in bladder and salivary gland. Database analysis identified GGCT orthologs in a range of species from C. elegans to mammals, but not in plants.GGO-induced apoptosis was inhibited by a dominant-negative mutation of JNK (MAPK8) that impeded JNK signaling, suggesting involvement of JNK and CRF21 in GGO-induced apoptosis.The enzymatic kinetics were similar to those of GGCT purified from human erythrocytes.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a CLIA Kit for Gamma-Glutamylcyclotransferase (gGCT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Gamma-Glutamylcyclotransferase (gGCT) ELISA Kit Customized Service Offer