Gap Junction Protein Alpha 3 (GJa3)

Using a rat cDNA probe in Southern analysis of a panel of human-mouse somatic cell hybrids, Willecke et al. (1990) assigned the GJA3 gene, which they referred to as CX46, to chromosome 13. Thus, both the GJB2 gene, or CX26, and CX46 map to chromosome 13. Hsieh et al. (1991) also mapped the GJA3 gene to chromosome 13, probably near the GJB2 gene, by probing somatic cell hybrid DNAs on Southern filters. By a comparable method, they mapped the gene in the mouse to chromosome 14. (There was hybridization also with mouse chromosome 5.) By isotopic in situ hybridization, Mignon et al. (1996) mapped the GJA3 gene to 13q11-q12 and confirmed the assignment to mouse chromosome 14.