General Control Of Amino Acid Synthesis 1 Like Protein 1 (GCN1L1)

In S. cerevisiae, amino acid starvation causes increased transcription of genes encoding enzymes involved in amino acid biosynthesis.This process, known as general amino acid control, requires the phosphorylation of translation initiation factor eIF2 by protein kinase GCN2 and subsequent derepression of GCN4, a transcriptional activator that binds to the promoter of genes subject to the general control. GCN1L1 encodes a deduced 2,412-amino acid protein that shares homology with the S. cerevisiae protein GCN1. The portion of GCN1L1 that is highly conserved with yeast GCN1 also shows sequence similarity to yeast EF3. This conserved domain supports the hypothesis that GCN1L1 performs an EF3-related function on the ribosome by regulating GCN2 kinase activity.