General Transcription Factor IIH, Polypeptide 5 (GTF2H5)

TTD; TFB5; TGF2H5; TTD-A; TTDA; C6orf175; DNA Repair Syndrome Trichothiodystrophy Group A; TFIIH basal transcription factor complex TTD-A subunit

General Transcription Factor IIH, Polypeptide 5 (GTF2H5)
General Transcription Factor IIH,Polypeptide 5 is a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A.
This protein, called TFB5, is a core component of yeast general transcription and DNA repair factor IIH (TFIIH). Database screening identified a human homolog of 71 amino acids that shares 28% identity with the yeast protein. Giglia-Mari et al. (2004) cloned the human cDNA corresponding to the TFB5 gene from primary fibroblasts.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

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Organism species: Rattus norvegicus (Rat)

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  • Customized Service n/a Monoclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Monoclonal Antibody Customized Service Offer
  • Customized Service n/a Polyclonal Antibody to General Transcription Factor IIH, Polypeptide 5 (GTF2H5) Polyclonal Antibody Customized Service Offer
  • Customized Service n/a CLIA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) CLIA Kit Customized Service Offer
  • Customized Service n/a ELISA Kit for General Transcription Factor IIH, Polypeptide 5 (GTF2H5) ELISA Kit Customized Service Offer