Glutamate Receptor, Ionotropic, Delta 2 Interacting Protein (GRId2IP)

Glutamate receptor delta-2 (GRID2) is predominantly expressed at parallel fiber-Purkinje cell postsynapses and plays crucial roles in synaptogenesis and synaptic plasticity. GRID2IP1 interacts with GRID2 and may control GRID2 signaling in Purkinje cells.

The L-delphilin isoform contains an N-terminal PDZ domain (PDZ1), followed by a linker region, a second PDZ domain (PDZ2), an FH domain, and a C-terminal coiled-coil domain. Compared with L-delphilin, S-delphilin lacks PDZ1 and the linker region, which are replaced with an N-terminal palmitoylation site. Northern blot analysis of mouse brain showed higher expression of S-delphilin in cerebral cortex than cerebellum, whereas L-delphilin showed higher expression in cerebellum.