Glutamate Receptor Interacting Protein 2 (GRIP2)

The recruitment of signaling molecules to the plasma membrane is a prerequisite for the functioning of various signaling cascades. Correct localization within the plasma membrane is equally important, as the membrane itself is highly organized into lipid domains that provide subcompartments.

Glutamate receptor-interacting protein 2 is a protein encoded by the GRIP2 gene.May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4