Glutathione S Transferase Zeta 1 (GSTz1)

GSTZ1 is a member of the GSTs super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms.Human GSTZ1-1 was 38% and 49% identical to the carnation and C. elegans proteins, respectively. The authors found that recombinant human GSTZ1-1 was a dimer composed of 24.2-kD subunits. GSTZ1-1 was most abundant in liver, with lower levels detected in skeletal muscle and brain.