Glycerol Kinase 2 (GK2)

Sargent et al. (1994) suggested that the human glycerol kinase gene family consists of at least 3 expressed loci. The GK1 locus on Xp21.3 is the site of mutations (deletions) causing glycerol kinase deficiency. It comprises 19 exons and is probably ancestral to several other genes which, because they are intronless, are suspected of having arisen by reverse transcriptase mediated events. These include 2 genes on chromosome 4. They are expressed as a single mRNA species in testis where expression is at a high level.

By fluorescence in situ hybridization, Sargent et al. (1994) demonstrated that one of the testicular forms of GK is encoded by a gene at 4q13 and the other by a gene at 4q32.