Glycophorin B (GYPB)

CD235b; GYP-B; SS; PAS-3; MNS; GPB; GYPA; GPB.NY; GYPHe.NY; Sialoglycoprotein Delta And SS-active Sialoglycoprotein

Glycophorin B (GYPB)

  • Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups.

  • GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified.

  • These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB.

Organism species: Homo sapiens (Human)