Glycophorin E (GYPE)

GYP-E; MNS; GPE; MiIX

Glycophorin E (GYPE)
A Glycophorin is a sialoglycoprotein of the membrane of a red blood cell. It is a membrane-spanning protein and carries sugar molecules. It is heavily glycosylated (60%). Glycophorins are rich in sialic acid, which gives the red cells a very hydrophilic-charged coat. This enables them to circulate without adhering to other cells or vessel walls.
Glycophorin-E is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.

Organism species: Homo sapiens (Human)