Golgin A1 (GOLGA1)

Griffith et al. (1997) used serum from a Sjogren syndrome patient with scleroderma to isolate a cDNA strand encoding a Golgi complex antigen from a HeLa cell cDNA library. The clone encoded a predicted 767-amino acid protein with a pI of 5.09, a granin motif, and coiled-coil domains. On Western blots of HeLa cell extracts, the encoded protein migrated at 97 kD, and so Griffith et al. (1997) named it 'golgin-97.' Antibodies to golgin-97 stained the Golgi complex.

BRCA1 plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. BRCA1 forms several distinct complexes through association with different adaptor proteins, and each complex forms in a mutually exclusive manner.