Grainyhead Like Protein 1 (GRHL1)

GRHL1 encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development.

Huang and Miller (2000) cloned GRHL1, which they designated LBP32. The deduced 618-amino acid protein has a calculated molecular mass of 68 kD. RT-PCR followed by Southern blot analysis detected prominent expression of LBP32 in the JEG-3 cell line only, with little to no expression in human HepG2, NCI-H295A, and HeLa cell lines, human adrenal tissue, and monkey COS-1 cells.