Guanylate Kinase 1 (GUK1)

Guanylate kinase (EC 2.7.4.8) catalyzes the transfer of phosphate from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) or dGMP. This enzyme functions in the recovery of cGMP and is, therefore, thought to regulate the supply of guanine nucleotides to signal transduction pathways. See GUK2 and GUK3 , isoforms believed to be determined by separate loci.

Brady et al. (1996) cloned human and mouse cDNAs of GUK1. They reported that the human gene predicts a protein of 197 amino acids with a mass of 21.7 kD. They found that the 1-kb message was ubiquitously expressed. Brady et al. (1996) published a computer model of GUK1 tertiary structure designed to be used in the development of chemotherapy drugs.