HIRA Interacting Protein 5 (HIRIP5)

The HIRIP5 cDNA contains 3 putative start methionines, resulting in deduced proteins of 230, 196, and 169 amino acids. The 3 start codons in the human sequence are conserved in mouse, but the first is out of frame. Translation from the first conserved in-frame start codon in mouse yields a 199-amino acid protein that is 97% identical to the 196-amino acid human protein. Alignment of HIRIP5 homologs revealed a protein structure consisting of an N-terminal domain with 5 conserved residues; a central domain with 8 conserved residues; a linker region; a C-terminal domain; and a variable C terminus. HIRIP5 may have a mitochondrial localization signal. Northern blot analysis detected a 1.1-kb transcript in nearly all adult and fetal tissues examined