HIV1 Rev Binding Protein 2 (HRB2)

In yeast, Krr1 is a component of a ribonucleoprotein required for biogenesis of the 18S rRNA. By database analysis, Bernstein et al. (2004) identified human KRR1.

By searching a human database for sequences similar to Drosophila dribble (dbe), Chan et al. (2001) identified the human ortholog, KRR1. Dribble and KRR1 share highest similarity in their ribonucleoprotein K (HNRNPK) homology (KH) domains. In Drosophila, dribble localized to the nucleus, and in some cell types to a subregion of the nucleolus.Chan et al. (2001) found that dribble was required for survival of dividing cells during Drosophila development. Dribble mutants showed a defect in rRNA processing and accumulated abnormal rRNA precursors.