HIV1 Tat Interactive Protein 2 (HTATIP2)

TC3 shares its N-terminal domain with CC3 but has a short, unique C terminus. Western blot analysis detected CC3 predominantly in membrane and nuclear fractions but not in the cytoplasm, whereas TC3 was predominantly in membrane fractions. The authors determined that the potent proapoptotic activity of CC3 resides in the N-terminal domain; however, the short C terminus of TC3 confers upon it antiapoptotic properties capable of inhibiting apoptosis induced by CC3 and other death stimuli.The deduced 242-amino acid protein is evolutionarily conserved and lacks known protein domains. Introduction of CC3 into v-SCLC cells resulted in a significant suppression of metastasis in a SCID-hu mouse model, as well as massive and rapid cell death in vitro through apoptosis.