Hairy And Enhancer Of Split 3 (HES3)

By searching databases using mouse Hes3 as query, Katoh and Katoh (2004) identified human HES3. The deduced 186-amino acid protein contains an N-terminal basic helix-loop-helix domain, followed by an orange domain, a proline-rich domain, and a C-terminal WRPW motif.Katoh and Katoh (2004) determined that the HES3 gene contains at least 3 exons.By genomic sequence analysis, Katoh and Katoh (2004) mapped the HES2 and HES3 genes to chromosome 1p36.31.

The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins