HECT Domain And RCC1 Like Domain Protein 6 (HERC6)

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins.

The deduced 1,022-amino acid protein contains an N-terminal RLD and a C-terminal HECT domain.Confocal immunofluorescence microscopy of transiently transfected HeLa cells showed HERC6 in a punctate cytoplasmic distribution.HERC6 gene contains 23 exons, with the initiation codon in exon 1.