Heparan Sulfate-3-O-Sulfotransferase 1 (HS3ST1)

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.

The predicted 307-amino acid human 3OST protein shares 93% sequence similarity with mouse 3Ost. The 3OST protein contains a signal sequence and 5 potential N-glycosylation sites.