Heparan Sulfate-3-O-Sulfotransferase 2 (HS3ST2)

The 3OST2 gene encodes a predicted 367-amino acid protein that, like 3OST3A1 and 3OST3B1, is a predicted type II integral membrane protein. These 3 enzymes contain a positively charged N-terminal domain, a transmembrane domain, a region termed the SPLAG domain because it is rich in serine, proline, leucine, alanine, and glycine, and a C-terminal putative sulfotransferase domain.

Although they share a similar regional structure, the only significant sequence homology between these 3OST proteins occurs in the sulfotransferase domains. Northern blot analysis revealed that the 3OST2 and 3OST4 genes were expressed predominantly in brain, while the 3OST3 gene exhibited more widespread expression.