Heterogeneous Nuclear Ribonucleoprotein A3 (HNRPA3)

By screening a human fetal brain cDNA library with sequences obtained from an approximately 1-Mb contig at the D10S102 locus, which is tightly linked to the locus for multiple endocrine neoplasia type II (MEN2), Takiguchi et al. (1993) isolated a cDNA encoding HNRNPA3, which they designated FBRNP. SDS-PAGE analysis showed that the deduced 270-amino acid protein, which shows significant homology to the murine heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), is expressed as a 32-kD protein.

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are complexes of RNA and protein present in the cell nucleus during gene transcription and subsequent post-transcriptional modification of the newly synthesized RNA (pre-mRNA).