Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2)
L3
HEXIM2, a previously predicted protein with sequence similarity to HEXIM1.Regulates positive transcription elongation factor b through association with 7SK. HEXIM2 is expressed in HeLa and Jurkat cells, and glycerol gradient analysis and immunoprecipitations indicate that HEXIM2, like HEXIM1, has a regulated association with P-TEFb. As HEXIM1 is knocked down, HEXIM2 functionally compensates for its association with P-TEFb. Electrophoretic mobility shift assays and in vitro kinase assays demonstrate that HEXIM2 forms complexes containing 7SK and P-TEFb and, in conjunction with 7SK, inhibits P-TEFb kinase activity.HEXIM2 is a regulator of P-TEFb function. The utilization of HEXIM1 or HEXIM2 to bind and inhibit P-TEFb can be differentially regulated in vivo.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Hexamethylene Bis Acetamide Inducible Protein 2 (HEXIM2) ELISA Kit Customized Service Offer