Histone Cluster 1, H1e (HIST1H1E)

HIST1H1E is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

By in situ hybridization, Tanguay et al. (1987) mapped the histone H1.4 gene to chromosome 12q11-q21. On the other hand, Albig et al. (1993) mapped 6 H1 genes, including H1.4, to chromosome 6p22.1-p21.1. By analysis of a YAC contig, Albig et al. (1997) mapped the H1.4 gene to chromosome 6p21.3, within a cluster of 35 histone genes.By genomic sequence analysis, Marzluff et al. (2002) determined that the histone gene cluster on chromosome 6p22-p21, which they called histone gene cluster-1 (HIST1), contains 55 histone genes, including HIST1H1E.