Histone Cluster 1, H2bc (HIST1H2BC)

Histones are basic nuclear proteins that are responsible for the nucleosome structure within the chromosomal fiber in eukaryotes. Albig and Doenecke (1997) found 1 H1 gene (H1.5), 5 H2A genes, 4 H2B genes, 1 H2B pseudogene, 3 H3 genes, 3 H4 genes, and 1 H4 pseudogene. The dinucleotide repeat polymorphic marker D6S105 was localized at the telomeric end of this histone gene cluster. Almost all human histone genes isolated to that time had been localized within the 2 clusters on 6p or in a small group of histone genes on chromosome 1.

By analysis of a YAC contig from chromosome 6p21.3, Albig et al. (1997) characterized a cluster of 35 histone genes, including H2B/l.