Histone Cluster 1, H2bn (HIST1H2BN)

Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.

HIST1H2BN is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.Albig and Doenecke (1997) characterized a second cluster of 16 histone genes, including H2B/d, located 2 Mb centromeric to the major histone gene cluster.