Homeobox Protein B5 (HOXB5)

HOXB5 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. The homeobox sequence on chromosome 17 in man should be called HOX2 because it is homologous to the gene first found and so designated in the mouse. The homeobox cluster on chromosome 17 has been called HOX2 or HOXB.