Homeobox Protein B6 (HOXB6)

HOXB6 is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain.The protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. The resulting Hox-2.2 misexpression produced early postnatal lethality as well as craniofacial and axial skeletal perturbations that included open eyes at birth, cleft palate, micrognathia, microtia, skull bone deficiencies, and structural and positional alterations in the vertebral column.