Homocysteine Inducible, Endoplasmic Reticulum Stress Inducible, Ubiquitin Like Domain Member 1 (HERPUD1)

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system.

This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. The full-length nature of all transcript variants has not been determined.