15-Hydroxyprostaglandin Dehydrogenase (HPGD)

SDR36C1; PGDH1; 15-PGDH; Prostaglandin dehydrogenase 1; Short Chain Dehydrogenase/Reductase Family 36C,Member 1
15-Hydroxyprostaglandin Dehydrogenase (HPGD)
Prostaglandins are involved in many physiologic and cellular processes, such as inflammation. Pichaud et al. (1997) noted that the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH, type I) is the main enzyme of prostaglandin degradation. By catalyzing the conversion of the 15-hydroxyl group of prostaglandins into a keto group, this ubiquitous enzyme strongly reduces the biologic activity of these molecules. The nucleotide sequence coding for PGDH1 was established by Ensor et al. (1990) who found an 801-bp open reading frame coding for a protein with 266 amino acids identical to the amino acid sequence established by Krook et al. (1990).Cortisol reduces the activity of PGDH in human placental cells. 11-beta hydroxysteroid dehydrogenase type II (HSD11B2) converts cortisol to cortisone.
Organism species: Homo sapiens (Human)
  • Protein RPH885Hu01Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyPAH885Hu01Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyMAH885Hu21Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSEH885HuELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSCH885HuCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPH885Mu01Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyPAH885Mu01Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyMAH885Mu21Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSEH885MuELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSCH885MuCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPH885Ra01Recombinant 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyPAH885Ra01Polyclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • AntibodyMAH885Ra21Monoclonal Antibody to 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSEH885RaELISA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
  • Assay KitSCH885RaCLIA Kit for 15-Hydroxyprostaglandin Dehydrogenase (HPGD)Customize
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