Hypermethylated In Cancer 1 (HIC1)

Hic1 encodes a zinc finger protein with a poxvirus and zinc finger (POZ) domain. During embryonic development, Hic1 is expressed in mesenchymes of the sclerotomes, lateral body wall, limb, and craniofacial regions embedding the outgrowing peripheral nerves during their differentiation. During fetal development, Hic1 is also expressed in mesenchymes apposed to the precartilaginous condensations, at many interfaces to budding epithelia of inner organs, and weakly in musclesThe BTB/POZ domains of HIC1 and HIC2 heterodimerized and repressed transcription from a reporter plasmid. Inhibitor studies indicated that HIC1 and HIC2 do not recruit HDAC-containing complexes. The central GLDLSKK/R motif, which is conserved in HIC1 and HIC2, was found to interact with C-terminal-binding protein.