Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)

Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)
HCN4 encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. The HCN4 cDNA predicts a protein of 1,203 amino acids. HCN4 contains 6 putative transmembrane segments, a pore region, and a cyclic nucleotide-binding domain (CNBD). Northern blot and PCR analyses showed that HCN4 is expressed at heart ventricle and atrium.
Organism species: Homo sapiens (Human)
  • Protein RPH925Hu01Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyPAH925Hu01Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyMAH925Hu21Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSEH925HuELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSCH925HuCLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPH925Mu01Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyPAH925Mu01Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyMAH925Mu21Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSEH925MuELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSCH925MuCLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPH925Ra01Recombinant Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyPAH925Ra01Polyclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • AntibodyMAH925Ra21Monoclonal Antibody to Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSEH925RaELISA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
  • Assay KitSCH925RaCLIA Kit for Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4 (HCN4)Customize
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