INO80 Homolog (INO80)

INOC1 is the human homolog of S. cerevisiae Ino80, the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INOC1 defines a subfamily of SWI2/SNF2 chromatin remodeling proteins.The deduced 1,556-amino acid INOC1 protein has a predicted molecular mass of 177 kD. The protein contains the conserved 7-motif SNF2 helicase domain, which is dispersed over 700 amino acids rather than the typical 400. It has a typical GxGK[S/T] sequence in SNF domain motif-1, a DEAQ, rather than a DExH/D, pattern in motif-2, and a 126-amino acid domain, termed DBINO (DNA-binding domain of INO80), that is conserved in members of the INO80 subfamily and is located upstream of the SNF2 helicase domain. INOC1 contains both N-terminal and C-terminal nuclear localization signals.