IQ Motif And SEC7 Domain Containing Protein 2 (IQSEC2)

The IQSEC2 gene encodes a guanine nucleotide exchange factor for the ARF family of GTP-binding proteins.The longer isoform contains 15 exons and encodes a 1,488-residue protein, whereas the shorter isoform contains 14 exons and encodes a 949-residue protein. The proteins have 906 amino acids in common, which include the IQ, Sec7, and PH functional domains, but vary at both the N and C termini. An alternative transcript for the longer isoform, resulting in a 1,478-residue protein, was also proposed. Both the long and short isoforms were expressed in fetal and adult human brain.The deduced 1,560-amino acid protein shares weak homology with rat Sec7a. RT-PCR detected high expression of IQSEC2 in brain, kidney, and small intestine, and intermediate to low expression in placenta, pancreas, ovary, prostate, and liver.