Ibuprofen (IPF)

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used for relieving pain, alleviating fever, and reducing inflammation. Ibuprofen has an antiplatelet effect, though it is relatively mild and somewhat short-lived compared with aspirin or prescription antiplatelet drugs. Ibuprofen is used primarily for fever, pain, dysmenorrhea and inflammatory diseases such as osteoarthritis and rheumatoid arthritis. It is also used for pericarditis and patent ductus arteriosus. Ibuprofen is produced industrially as a racemate. The compound, like other 2-arylpropionate derivatives (including ketoprofen, flurbiprofen, naproxen, etc.), does contain a chiral center in the α-position of the propionate moiety. So two enantiomers of ibuprofen occur, with the potential for different biological effects and metabolism for each enantiomer. Indeed, the (S)-(+)-ibuprofen (dexibuprofen) was found to be the active form both in vitro and in vivo.