Inhibitor Of Growth Family, Member 3 (ING3)

ING3 is a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.The ING3 gene encodes a predicted 418-amino acid protein with a putative molecular mass of 47 kD. The protein shows high homology with other members of the ING family within the PHD zinc finger domain and weak overall homology with ING1.