Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Kinase Epsilon (IkBKe)

IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines .

Sequence analysis predicted that the 716-amino acid protein contains an N-terminal serine/threonine kinase domain and C-terminal leucine zipper and helix-loop-helix domains. Northern blot analysis revealed expression of a 4.0-kb transcript in spleen, thymus, peripheral blood leukocytes, pancreas, and placenta, with low expression in lung, kidney, prostate, ovary, and colon.