Inositol-1,4,5-Triphosphate Receptor Interacting Protein Like Protein 2 (ITPRIPL2)

ITPRIPL2 belongs to the ITPRIP family. ITPRIP Enhances Ca(2+)-mediated inhibition of inositol-1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Interacts with ITPR. Inositol 1,4,5-trisphosphate is a secondary messenger molecule used in signal transduction and lipid signaling in biological cells. While DAG stays inside the membrane, IP₃ is soluble and diffuses through the cell. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂), a phospholipid that is located in the plasma membrane, by phospholipase C. IP₃ binds to and activates the InsP₃ receptor on the membrane of the endoplasmic reticulum (ER) and sarcoplasmic reticulum (SR), opening a calcium channel, resulting in the release of Ca²⁺ into the cytoplasm and sarcoplasm, respectively. This increase in Ca²⁺ activates the ryanodine receptor-operated channel on the SR, leading to a further increase in the Ca²⁺.