Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)

IP3R; IP3R1; Insp3r1; SCA15; SCA16; Spinocerebellar Ataxia 15; IP3 receptor isoform 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)
ITPR1 encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. Inositol 1,4,5-triphosphate is an intracellular second messenger produced by phospholipase C through a G protein-dependent mechanism. It releases calcium from endoplasmic reticulum by binding to specific receptors that are coupled to calcium channels. These receptors are abundant in neuronal and nonneuronal tissues. The neuronal form of the receptor is abundant in the cerebellum, particularly the perikaryon of the Purkinje cells.
Organism species: Homo sapiens (Human)
  • Protein RPE845Hu01Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyPAE845Hu01Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyMAE845Hu21Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSEE845HuELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSCE845HuCLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPE845Mu01Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyPAE845Mu01Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyMAE845Mu21Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSEE845MuELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSCE845MuCLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPE845Ra01Recombinant Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyPAE845Ra01Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • AntibodyMAE845Ra21Monoclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSEE845RaELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
  • Assay KitSCE845RaCLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)Customize
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