Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)

IP3R; IP3R1; Insp3r1; SCA15; SCA16; Spinocerebellar Ataxia 15; IP3 receptor isoform 1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor

Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1)
ITPR1 encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. Inositol 1,4,5-triphosphate is an intracellular second messenger produced by phospholipase C through a G protein-dependent mechanism. It releases calcium from endoplasmic reticulum by binding to specific receptors that are coupled to calcium channels. These receptors are abundant in neuronal and nonneuronal tissues. The neuronal form of the receptor is abundant in the cerebellum, particularly the perikaryon of the Purkinje cells.

Organism species: Homo sapiens (Human)

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Organism species: Mus musculus (Mouse)

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  • Customized Service n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)

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  • Customized Service n/a Polyclonal Antibody to Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) Polyclonal Antibody Customized Service Offer
  • Customized Service n/a CLIA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) CLIA Kit Customized Service Offer
  • Customized Service n/a ELISA Kit for Inositol-1,4,5-Trisphosphate Receptor Type 1 (ITPR1) ELISA Kit Customized Service Offer