Insulin Like Growth Factor 2 mRNA Binding Protein 2 (IGF2BP2)

IGF2BP2 encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The deduced 598-amino acid protein has a calculated molecular mass of 66 kD. IMP2 contains 6 characteristic RNA-binding modules, including 2 N-terminal RRM domains and 4 central and C-terminal KH domains. It shares 59% amino acid identity with IMP1 and IMP3. The deduced 556-amino acid protein has a calculated molecular mass of 62 kD.