Interferon Alpha Inducible Protein 6 (IFI6)
FAM14C; G1P3; IFI-6-16; IFI616
IFI6was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. The antiapoptotic activity of IFN-alpha-2b was associated with increased expression of G1P3. Ectopically expressed G1P3 localized to mitochondria and antagonized TRAIL-mediated mitochondrial potential loss, cytochrome c release, and apoptosis. Conversely, RNA interference-mediated downregulation of G1P3 restored IFN-alpha-2b-induced apoptosis.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Interferon Alpha Inducible Protein 6 (IFI6) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Interferon Alpha Inducible Protein 6 (IFI6) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Interferon Alpha Inducible Protein 6 (IFI6) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Interferon Alpha Inducible Protein 6 (IFI6) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Interferon Alpha Inducible Protein 6 (IFI6) ELISA Kit Customized Service Offer