Interferon Induced Transmembrane Protein 6 (IFITM6)

Interferon Induced Transmembrane Protein 6 (IFITM6) Belongs to the CD225 family.Deblandre et al. (1995) identified a 17-kD membrane protein, IFI17, that was inducible on tumor cell lines by interferon-alpha and, usually to a lesser extent, by interferon-gamma (IFNG). CD225 Expression as detected by FACS analysis or immunoprecipitation was correlated with sensitivity of the cell lines to growth suppression by interferon.

Using mRNA extracted from HeLa cells incubated with interferon-alpha, the authors screened a cDNA expression library by panning with a monoclonal anti-IFI17. They obtained a cDNA sequence encoding a protein that is identical except for 1 residue to the 125-amino acid protein 9-27 that Reid et al. (1989) had isolated from a lymphoid cell cosmid library.