Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2)

IRF2BP2 encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. IRF-2BP1 and IRF-2BP2A/B contain an N-terminal zinc finger and a C-terminal RING finger domain of the C3HC4 subclass, but show no homology to other known transcriptional regulators; they therefore define a new family of co- repressor proteins.

IRF2BP2 interacts with NFAT1 and repress its transcriptional activity, suggesting that IRF2BP2 can be a new regulator of NFAT1 transcriptional activity. IRF2BP2 has an impact on the cellular stress response after Act.D treatment and that it diminishes the induction of apoptosis after doxorubicin treatment.