Interleukin 27A (IL27A)

Interleukin 27A, also called Interleukin-30 (IL-30), is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3).

IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6. This gene for this molecule is now officially called IL-27 under HGNC guidelines. IL27 is produced by antigen-presenting cells, and it mainly functions in innate immunity.