Interleukin Enhancer Binding Factor 2 (ILF2)

NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

The NF45 gene encodes a 405-amino acid polypeptide with distant similarity to DNA topoisomerase II and a prokaryotic RNA polymerase that melts DNA to initiate transcription. NF45 and NF90 were expressed in several cell types, including both unstimulated and stimulated Jurkat T cells.